When looking at the historical evolution of attitudes towards psychological disorders, general paresis is a disease with great significance because it

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General paresis, which is a severe neuropsychiatric disorder (a form of late-stage syphilis affecting the brain), provided the first clear evidence that a psychological disorder (in this case, symptoms including delusions of grandeur and other severe cognitive deficits) could have a direct biological cause (the Treponema pallidum bacterium). This was a pivotal moment in the history of psychology and psychiatry, as it shifted the understanding of mental illness towards biological underpinnings.

When Looking at the Historical Evolution of Attitudes Towards Psychological