A Patient Comes to the Hospital with a Severe Crush

A patient comes to the hospital with a severe crush injury of the leg. He is complaining of severe pain. He also says he is feeling very nauseous and, after a few minutes, vomits. What is the best explanation for the nausea and vomiting?

A) Chemicals released from tissues in the injured foot flooded the digestive system, producing nausea and vomiting.
B) Nociceptors from the lower limbs travel along a similar pathway as chemical receptors from the digestive tract, causing the body to confuse the location of the stimulus.
C) Pain signals traveling along the spinoreticular tract carried signals to the hypothalamus and limbic system, triggering nausea as a response to pain.
D) The spinothalamic tract relayed a signal to the thalamus and postcentral gyrus, which reacted to the pain by producing nausea.