The four disadvantages of simulation are cost, its trial-and-error nature, time compression, and uniqueness.

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The disadvantages of simulation include its potentially high cost and time-consuming nature, but time compression is actually an advantage of simulation as it allows for faster analysis of processes. Uniqueness refers to the fact that each simulation is specific to a particular problem, which can be both an advantage and a disadvantage. The trial-and-error nature is not universally recognized as a disadvantage; instead, it's part of the iterative process of model refinement.

The Four Disadvantages of Simulation Are Cost, Its Trial-And-Error Nature