Determine the Sequence of the Following Events in a Cell

Determine the sequence of the following events in a cell after exposure of the cell to a chemical signal. (1) increased synthesis of a protein
(2) the chemical signal combined with a cytoplasmic receptor
(3) an increase in the nuclear concentration of the chemical
(4) an increase in mRNA synthesis
(5) genes are activated

A) 2, 1, 3, 5, 4
B) 2, 4, 5, 3, 2
C) 2, 3, 5, 4, 1
D) 2, 3, 4, 5, 1
E) 1, 2, 3, 4, 5