Curare is a poison used by South American Indians. It is known to bind to ACh receptors preventing the binding of ACh. What effect would it have on muscle function? A) The muscle fibers would contract uncontrollably and continually. B) The muscle fibers would not contract because the Na⁺ channels which cause depolarization of the muscle fiber membrane are never signaled to open. C) The pre-synaptic release of ACh would be inhibited, therefore the muscle would not contract. D) The action of acetylcholinesterase would be inhibited causing increased contraction. E) Both the muscle fibers would contract uncontrollably and continually and the action of acetylcholinesterase would be inhibited causing increased contraction would occur.

Question

Quizplus · Accepted Answer

Curare prevents the binding of ACh to its receptors, which are necessary to cause depolarization of the muscle fiber membrane. Without depolarization, the Na⁺ channels would not be signaled to open, and therefore the muscle fibers would not contract.

Curare Is a Poison Used by South American Indians