A child develops retinoblastoma. Which of the following must have occurred?

Question

Quizplus · Accepted Answer

Retinoblastoma is caused by mutations in both copies of the rb gene, which is a tumor suppressor gene. When both copies are mutated, the cell loses its ability to regulate cell division and tumors can form. Activation of the rb gene or the apoptosis gene would not directly result in retinoblastoma, and only one mutation in the rb gene would not be enough to cause the disease.

A Child Develops Retinoblastoma