A 35-year-old female is diagnosed with multiple myeloma. Biopsy of the tumor reveals Russell bodies, and laboratory testing reveals kidney dysfunction. Accumulation of which of the following is associated with these symptoms?
A) Glycogen
B) Protein
C) Pigment
D) Melanin

Question

Quizplus · Accepted Answer

Russell bodies are cytoplasmic inclusions composed of immunoglobulins that are typically found in plasma cells, which are the malignant cells in multiple myeloma. Excess production of immunoglobulins can lead to protein accumulation in the blood and contribute to kidney dysfunction. Glycogen accumulation is associated with glycogen storage diseases, pigments with jaundice or hemochromatosis, and melanin with melanoma.

A 35-Year-Old Female Is Diagnosed with Multiple Myeloma