A patient with a history of taking acetaminophen (Tylenol) for osteoarthritis pain is surprised to learn the diagnosis of liver failure. What should the nurse explain to the patient about this diagnosis? Select all that apply.

Question

Quizplus · Accepted Answer

1. When the maximum daily dose is repeatedly exceeded, the normal pathways of metabolism become saturated and more of the toxic metabolite is produced.
2. When hepatic glutathione stores are depleted, the toxic substances accumulate, causing hepatic injury.
3. The minimal dose that produces liver injury varies between 4 to 10 grams.
4. The minimal dose that produces liver injury varies between 4 to 10 grams per day.
5. Liver damage from acetaminophen occurs with or without the ingestion of alcohol.

A Patient with a History of Taking Acetaminophen (Tylenol) for Osteoarthritis