Unlike cytotoxic T cells,natural killer cells do not require antigen to be complexed with class I MHC proteins in order to bind to the antigen.

Question

Quizplus · Accepted Answer

Natural killer cells can recognize and bind to cells that are missing or have reduced levels of class I MHC proteins, which usually present self-antigens. This allows them to detect and target virally infected cells, as well as tumor cells, which may downregulate class I MHC to avoid recognition by cytotoxic T cells.

Unlike Cytotoxic T Cells,natural Killer Cells Do Not Require Antigen