What is the principle defect in Parkinson disease?
A) There is a loss of neurons in the reticular activating system that secrete acetylcholine.
B) There is a demyelination of alpha motor neurons important for posture and balance.
C) Neurons of the substantia nigra degenerate and there is reduced delivery of dopamine to the basal nuclei.
D) Autoimmune destruction occurs in neurons in the motor regions of the cerebral cortex.
E) Damage to neurons of the cerebellum reduces the coordination of muscle movements.

Question

Quizplus · Accepted Answer

Parkinson's disease is characterized by the degeneration of neurons in the substantia nigra, which results in a reduced delivery of dopamine to the basal nuclei. This leads to the symptoms of tremors, rigidity, and difficulty with initiating movements.

What Is the Principle Defect in Parkinson Disease