How does the chemical curare affect skeletal muscle function?
A) It activates an autoimmune disease that destroys myelin.
B) It blocks the action of acetylcholinesterase at the neuromuscular junction.
C) It is a muscarinic acetylcholine receptor antagonist that blocks synaptic transmission at the neuromuscular junction.
D) It is a nicotinic acetylcholine antagonist that blocks synaptic transmission at the neuromuscular junction.
E) It locks ligand-gated channels in the open state, leading to spastic contractions of muscle.

Question

Quizplus · Accepted Answer

Curare is a nicotinic acetylcholine antagonist that binds to the nicotinic acetylcholine receptors on the motor end plate, preventing acetylcholine from binding to the receptors and thus blocking synaptic transmission at the neuromuscular junction. This results in paralysis of the skeletal muscles.

How Does the Chemical Curare Affect Skeletal Muscle Function