In pioneering research with the sea slug Aplysia,Kandel and colleagues demonstrated that,after generating a strong gill-withdrawal response by delivering a shock to the tail of Aplysia,even light touches to the tail would provoke gill withdrawal for some period of time.This finding demonstrates the behavioural principle of:

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The phenomenon described, where a weaker stimulus initiates a response that was stronger before, is known as sensitization. This occurs in response to a prior strong stimulus, such as the shock to the tail of Aplysia in this case.

In Pioneering Research with the Sea Slug Aplysia,Kandel and Colleagues