Which combination of substances would cause the greatest stimulation of gastric HCL secretion when applied to parietal cells?

Question

Quizplus · Accepted Answer

Gastrin, histamine, and acetylcholine are known as the "gastric triad" and work together to stimulate gastric HCL secretion. Gastrin is released by G-cells in response to food entering the stomach, and it stimulates the parietal cells to produce HCL. Histamine is produced by enterochromaffin-like (ECL) cells in response to gastrin and acetylcholine, and it directly stimulates the parietal cells to secrete HCL. Acetylcholine is released by the vagus nerve and stimulates both gastrin and ECL cell production of histamine. Therefore, the combination of gastrin, histamine, and acetylcholine would cause the greatest stimulation of gastric HCL secretion.

Which Combination of Substances Would Cause the Greatest Stimulation of Gastric