Most psychoactive drugs produce their effects primarily by acting on:

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Psychoactive drugs, including drugs of abuse and medications used for mental health disorders, primarily produce their effects by acting on neurotransmitters in the brain. These drugs can increase or decrease the availability or activity of specific neurotransmitters, which can alter mood, perception, behavior, and other aspects of brain function. Hormones, the hypothalamus, and the autonomic nervous system can also be affected by psychoactive drugs, but these effects are typically secondary to changes in neurotransmitter activity.

Most Psychoactive Drugs Produce Their Effects Primarily by Acting On