Which of the Following Changes Have the Potential to Dramatically

Which of the following changes have the potential to dramatically affect the potential difference across the plasma membrane?

A) increased permeability of the membrane to sodium ions
B) increased intracellular concentration of potassium ions
C) any change in the rate at which the sodium-potassium pump works
D) increased permeability of the membrane to sodium ions and increased intracellular concentration of potassium ions
E) increased permeability of the membrane to sodium ions,increased intracellular concentration of potassium ions and any change in the rate at which the sodium-potassium pump works