Determine the Sequence of the Following Events in a Cell

Determine the sequence of the following events in a cell after exposure of the cell to a chemical signal. (1) increased synthesis of a protein
(2) the chemical signal combined with a cytoplasmic receptor
(3) an increase in the nuclear concentration of the chemical
(4) an increase in mRNA synthesis
(5) genes are activated

A) 1,2,3,4,5
B) 2,1,3,5,4
C) 2,4,5,3,2
D) 2,3,5,4,1
E) 2,3,4,5,1