Which of the following led to large-scale serious health problems among Indigenous peoples?

Question

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Contact with Europeans brought new diseases to Indigenous populations for which they had no immunity, causing large-scale serious health problems. This includes smallpox, measles, tuberculosis, and others. While alcohol did also contribute to health issues, it was not the primary factor. Contact with European animals and medicine did not necessarily lead to large-scale serious health problems.

Which of the Following Led to Large-Scale Serious Health Problems