Which Statements Describe Cofactors and Coenzymes? Select the TWO Answers

Which statements describe cofactors and coenzymes? Select the TWO answers that are correct.

A) Cofactors are made of protein,whereas coenzymes are any other macromolecule.
B) Cofactors and coenzymes both facilitate the binding of enzymes to substrates.
C) Cofactors can be organic or inorganic molecules,whereas coenzymes are only organic.
D) Cofactors and coenzymes both facilitate binding of enzymes to active sites.
E) Cofactors must work with enzymes,whereas coenzymes can work independently.