Which of the Following Steps (In Order)would Most Likely Lead

Which of the following steps (in order) would most likely lead to tumor formation?

A) A mutation in a single cell-cycle gene occurs,then the cell rapidly divides and spreads.
B) A mutated tumor-suppressor gene is inherited,several proto-oncogenes become mutated,and the cell dies.
C) A mutation in a cell-cycle gene occurs,then shortly afterwards the cell dies.
D) A mutated tumor-suppressor gene is inherited,other mutations in proto-oncogenes occur,and the cell rapidly divides and spreads.
E) A proto-oncogene is inherited,mutation converts it into an oncogene,and the cell rapidly divides and spreads.