How Does an Acquired Mutation in a Gene Alter the Function

How does an acquired mutation in a gene alter the function of a cell?

A) Base pair changes in the gene are passed directly into altered amino acids by a ribosome.
B) Base pair mutations in a gene are passed directly into mRNA via translation.
C) Base pair mutations in mRNA are passed directly into a protein via transcription.
D) Base pair mutations in a gene are passed directly into mRNA via transcription.
E) Base pair mutations in a gene are passed from mRNA into a protein via transcription.