G-quartets are G-rich single-stranded tails that loop back on themselves forming G-G double stranded sections.Such looping is involved in aligning chromosomes for homologous recombination.

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G-quartets (or G-quadruplexes) are secondary structures formed in nucleic acids by sequences that are rich in guanine. They are characterized by the stacking of G-quartets, which are square planar arrangements of four guanine bases connected through Hoogsteen hydrogen bonds, not by looping back on themselves to form G-G double-stranded sections. Their role is more related to the regulation of gene expression, telomere maintenance, and other cellular processes rather than aligning chromosomes for homologous recombination.

G-Quartets Are G-Rich Single-Stranded Tails That Loop Back on Themselves