Phenyl-methane-sulfonyl-fluoride (PMSF)inactivates serine proteases by binding covalently to the catalytic serine residue at the active site;this enzyme-inhibitor bond is not cleaved by the enzyme.This is an example of what kind of inhibition?

Question

Quizplus · Accepted Answer

Phenyl-methane-sulfonyl-fluoride (PMSF) forms a covalent bond with the catalytic serine residue at the active site of serine proteases, which cannot be cleaved by the enzyme. This irreversible inhibition is a characteristic feature of covalent or irreversible inhibitors.

Phenyl-Methane-Sulfonyl-Fluoride (PMSF)inactivates Serine Proteases by Binding Covalently to the Catalytic