A transition-state analog:
A) is less stable when binding to an enzyme than the normal substrate.
B) resembles the active site of general acid-base enzymes.
C) resembles the transition-state structure of the normal enzyme-substrate complex.
D) stabilizes the transition state for the normal enzyme-substrate complex.
E) typically reacts more rapidly with an enzyme than the normal substrate.

Question

Quizplus · Accepted Answer

Transition-state analogs are designed to resemble the transition-state structure of the normal enzyme-substrate complex, not the substrate itself, which allows them to bind more tightly to the enzyme than the substrate does.

A Transition-State Analog