Which of the following statements about protein-ligand binding is correct? A)The K_a is equal to the concentration of ligand when all of the binding sites are occupied. B)The K_a is independent of such conditions as salt concentration and pH. C)The larger the K_a (association constant),the weaker the affinity. D)The larger the K_a,the faster is the binding. E)The larger the K_a,the smaller the K_d (dissociation constant).

Question

Quizplus · Accepted Answer

The dissociation constant (K_d) is the inverse of the association constant (K_a). Therefore, the larger the association constant, the smaller the dissociation constant. This means that a larger association constant indicates a stronger binding affinity between the protein and ligand.

Which of the Following Statements About Protein-Ligand Binding Is Correct