An allosteric interaction between a ligand and a protein is one in which:
A) binding of a molecule to a binding site affects binding of additional molecules to the same site.
B) binding of a molecule to a binding site affects binding properties of another site on the protein.
C) binding of the ligand to the protein is covalent.
D) multiple molecules of the same ligand can bind to the same binding site.
E) two different ligands can bind to the same binding site.

Question

Quizplus · Accepted Answer

Allosteric interactions involve a conformational change in a protein that affects its binding properties at a different site. This means that binding of a ligand to one site on the protein can affect the ability of another site on the protein to bind to a different ligand. Option A is partially correct, but it only describes one aspect of allosteric interactions. Option C is incorrect because allosteric interactions are not covalent. Options D and E are incorrect because they refer to binding within a single binding site, rather than between multiple sites on the protein.

An Allosteric Interaction Between a Ligand and a Protein Is