Ubiquitin-mediated protein degradation is a complex process, and many of the signals remain unknown. One known signal involves recognition of amino acids in a processed protein that are either stabilizing (Ala, Gly, Met, Ser, etc.) or destabilizing (Arg, Asp, Leu, Lys, Phe, etc.) and are located at:

Question

Quizplus · Accepted Answer

The N-end rule pathway of ubiquitin-mediated protein degradation involves the recognition of proteins based on the identity of their N-terminal (amino-terminus) residue, which can signal them for degradation.

Ubiquitin-Mediated Protein Degradation Is a Complex Process, and Many of the Signals