A commonality between type I and type II topoisomerases is that they both:

Question

Quizplus · Accepted Answer

Both type I and type II topoisomerases go through a mechanism involving a covalent enzyme-substrate intermediate. Type I topoisomerases cleave one strand of DNA at a time, changing the linking number in increments of 1, while type II topoisomerases cleave both strands of DNA simultaneously, changing the linking number in increments of 2. Both types of topoisomerases may require ATP, but this is not a universal requirement. Quinoline antibiotics specifically target type II topoisomerases, but do not inhibit type I topoisomerases. Therefore, the best choice is C.

A Commonality Between Type I and Type II Topoisomerases Is