Indicate whether the following statements are true (T) or false (F).
___ The linking number (Lk) of a closed-circular DNA molecule can be changed only by breaking one or both strands.
___ DNA of all organisms is overwound (i.e., positively supercoiled).
___ Topoisomerase I relaxes DNA that is highly negatively supercoiled.

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The Answer of Indicate whether the following statements are true (T) or false (F).
___ The linking number (Lk) of a closed-circular DNA molecule can be changed only by breaking one or both strands.
___ DNA of all organisms is overwound (i.e., positively supercoiled).
___ Topoisomerase I relaxes DNA that is highly negatively supercoiled.

Indicate Whether the Following Statements Are True (T) or False