Transport of fatty acids from the cytoplasm to the mitochondrial matrix requires:

Question

Quizplus · Accepted Answer

Transport of fatty acids from the cytoplasm to the mitochondrial matrix requires ATP, carnitine, and coenzyme A. The fatty acid is first activated by reacting with CoA in the cytosol to form fatty-acyl-CoA, which then reacts with carnitine to form fatty-acyl-carnitine. This is transported across the mitochondrial inner membrane using a carnitine-acylcarnitine translocase. Once inside the mitochondrial matrix, the fatty-acyl-carnitine is converted back to fatty-acyl-CoA by the action of carnitine palmitoyltransferase II (CPTII), which regenerates carnitine, and the fatty-acyl-CoA is then broken down by beta-oxidation. ATP is required for the activation of the fatty acid and for the translocation of carnitine-acylcarnitine into the mitochondrial matrix.

Transport of Fatty Acids from the Cytoplasm to the Mitochondrial