In the first step of fatty acid oxidation,the fatty acid (R-COOH)is converted to its coenzyme A derivative in the following reaction:
R-COOH + ATP + CoA-SH R-CO-S-CoA + AMP + PPi
The standard free-energy change ( G'° )for this reaction is -15 kJ/mol
What will tend to make the reaction even more favorable when it takes place within a cell?
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