Which of the following is not true for G protein-coupled receptors (GPCRs)?
A)Agonists mimic the effect of the natural ligand.
B)Antagonists block the normal effect of the natural ligand.
C)GPCRs interact with heterodimeric G proteins.
D)GPCRs are have seven transmembrane helices.
E)There exist 100 orphan GPCRs in the human genome with no known ligand.

Question

Which of the following is not true for G protein-coupled receptors (GPCRs)?
A)Agonists mimic the effect of the natural ligand.
B)Antagonists block the normal effect of the natural ligand.
C)GPCRs interact with heterodimeric G proteins.
D)GPCRs are have seven transmembrane helices.
E)There exist >100 orphan GPCRs in the human genome with no known ligand.

Quizplus · Accepted Answer

GPCRs interact with trimeric G proteins, not heterodimeric G proteins.

Which of the Following Is Not True for G Protein-Coupled