Following serum starvation,if normal fibroblasts were treated with cycloheximide to shut down cellular protein synthesis,then,when exposed to fresh serum,the cells would
A)Continue to remain viable in a quiescent state.
B)Express immediate early genes.
C)Enter a state of senescence.
D)Die.
E)None of the above.

Question

Quizplus · Accepted Answer

During serum starvation, normal fibroblasts enter quiescence and cellular protein synthesis shuts down. When exposed to fresh serum, the cells will express immediate early genes, which are genes that are rapidly induced by serum stimulation and are required for cell cycle entry and progression. This response is independent of protein synthesis, as cycloheximide shuts down protein synthesis but does not affect the induction of immediate early genes. Therefore, the cells will express immediate early genes even in the presence of cycloheximide.

Following Serum Starvation,if Normal Fibroblasts Were Treated with Cycloheximide to Shut