Which of the Following Would Be LEAST Likely to Contribute

Which of the following would be LEAST likely to contribute to transformation of a cell?

A) A mutation resulting in a change in splicing
B) A mutation in a transcription factor
C) A silent mutation in an intron
D) An activating mutation in an exon of a gene coding for a protein that promotes cellular proliferation
E) Changes in the expression level of a miRNA that is involved in protein synthesis