Which of the following is a mechanism by which tumors can evade immune detection? (Select all that apply.)

Question

Quizplus · Accepted Answer

Tumors can evade immune detection through various mechanisms including reduction in levels of HLA class I molecules (A), which are crucial for presenting tumor antigens to cytotoxic T cells, recruitment of regulatory T cells (B) that suppress immune responses, and lowering of levels of MHC class I polypeptide-related sequence A (MIC) on the cell surface (D), which can decrease NK cell-mediated killing of tumor cells. Enhancing inflammatory responses (C) typically aids in immune detection rather than evasion, and increasing levels of cancer/testis (CT) antigens (E) could potentially make tumor cells more recognizable to the immune system, not less.

Which of the Following Is a Mechanism by Which Tumors