It is believed that the allotype DRB1*_____ may confer protection against rheumatoid arthritis because it contains _____ amino acid residues at positions 70 and 71 that bind to different subsets of peptides compared with the allotypes that confer susceptibility to this disease.

Question

Quizplus · Accepted Answer

DRB1*04:02 contains arginine and serine residues at positions 70 and 71, respectively, which bind to a different set of peptides compared with the DRB1*04:01 and DRB1*04:04 alleles, which are associated with susceptibility to rheumatoid arthritis. DRB1*04:05 and DRB1*04:08 are not mentioned in the potential answers as having a specific association with rheumatoid arthritis.

It Is Believed That the Allotype DRB1*_____ May Confer Protection