Residual leukemia cells persisting in a patient after they have received chemotherapy,irradiation,and a bone-marrow transplant are sometimes eliminated by a _____ effect which involves the action of _____.(Select all that apply.)

Question

Quizplus · Accepted Answer

Graft-versus-leukemia effect involves the action of alloreactive T cells and/or NK cells which are capable of recognizing and killing residual leukemia cells while sparing normal cells. A haploidentical transplant (B) is a type of transplant where the donor and recipient are only partially matched in terms of their HLA antigens and requires extensive immunosuppression to prevent rejection. Acute minor histocompatibility (C) refers to minor antigen differences between the donor and recipient and can lead to graft-versus-host disease rather than graft-versus-leukemia effect. Myeloablation (D) refers to the destruction of the host's bone marrow to make space for donor cells and does not directly involve the immune system.

Residual Leukemia Cells Persisting in a Patient After They Have