Dominant mutant forms of IFNγR1 exhibit all of the following in heterozygotes except _____.

Question

Quizplus · Accepted Answer

Dominant mutant forms of IFNγR1 that exhibit a truncated cytoplasmic tail (B) can still form stable dimers with the normal form (C), but these dimers are unable to transduce signals effectively (E), leading to immunodeficiency. However, the severity of the immunodeficiency is less in heterozygotes than in individuals who are homozygous for recessive forms of the mutation (D). The incorrect statement is that these mutant forms are recycled by endocytosis more quickly than the normal receptor; this detail is not typically associated with the dominant mutant forms of IFNγR1.

Dominant Mutant Forms of IFNγR1 Exhibit All of the Following