Which of the Following Statements Regarding C1 Inhibitor (C1INH)is False

Which of the following statements regarding C1 inhibitor (C1INH) is false? (Select all that apply.)

A) C1INH belongs to a family of serine and cysteine protease inhibitors called the serpins.
B) C1INH inhibits C1r but not C1s,so partial serine protease activation is achieved in the classical complement pathway.
C) C1INH is cleaved by C1.
D) When bound to C1 as a pseudosubstrate,it activates the protease activity of C1.
E) Heterozygous individuals who have a single-gene defect in C1INH cannot make sufficient quantities of the gene product and must receive recombinant C1INH by infusion.