Which of the Following Explain Why Infections with Influenza Virus

Which of the following explain why infections with influenza virus erode immunological memory over time? (Select all that apply.)

A) Influenza is a highly mutable virus that changes its epitope composition.
B) A compensatory immune response to new epitope variants is suppressed in naive B cells.
C) The antibody response is directed only toward new epitope variants,resulting in a decreased memory response.
D) Cross-linking of B-cell receptor and FcγRIIB1 on memory B cells induces anergy.
E) Naive B cells are suppressed by cytokines made by memory B cells.