B cells migrating directly from a primary focus to the medullary cords in a lymph node after activation with a T-dependent antigen differentiate into plasma cells that secrete predominantly _____.

Question

Quizplus · Accepted Answer

After activation with a T-dependent antigen, B cells that migrate to the medullary cords differentiate into plasma cells that predominantly secrete IgM, which is the first antibody isotype produced in a primary immune response.

B Cells Migrating Directly from a Primary Focus to the Medullary