A. At which anatomical sites do naive T cells encounter antigen?
B. In which sites specifically would a pathogen or its antigens end up, and how would they be transported to these sites, if they (i) entered the body through a small wound in the skin, (ii) entered the body from the gut, or (iii) got into the bloodstream?
C. How do naive T cells arrive at these sites?
D. Do all T cells leave these locations after priming, and if so, how?
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