During cytokine signaling,_____ translocate(s)to the nucleus and direct(s)the upregulation of gene expression.

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STATs (signal transducers and activators of transcription) are transcription factors that translocate from the cytoplasm to the nucleus in response to cytokine signaling. Once in the nucleus, they bind to DNA and promote the transcription of target genes. Perforin and CD40 ligand are not involved in cytokine signaling, while TGF-β and CXCL2 are cytokines themselves and do not directly regulate gene expression through translocation to the nucleus.

During Cytokine Signaling,_____ Translocate(s)to the Nucleus and Direct(s)the Upregulation of Gene