In the absence of a co-receptor (CD4 or CD8 for T helper cells or cytotoxic T cells,respectively),T cells require _____ specific peptide:MHC complexes on the antigen-presenting cell compared with interactions involving a co-receptor.

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In the absence of a co-receptor, T cells require more specific peptide:MHC complexes on the antigen-presenting cell to be activated. Co-receptors like CD4 or CD8 enhance the sensitivity of T cell receptors to antigenic peptides presented by MHC molecules, allowing T cells to respond to lower concentrations of antigen. Without these co-receptors, a higher density of peptide:MHC complexes is necessary to achieve a similar level of T cell activation.

In the Absence of a Co-Receptor (CD4 or CD8 for T