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Indicate Which of the Following Statements Is True (T)or False

Question 18

Matching

Indicate which of the following statements is true (T)or false (F).

Premises:

Responses:

The expression of the pre-T-cell receptor is required in order to halt β-,γ-,and δ-chain rearrangements.

False

Allelic exclusion of the T-cell receptor α and β chains is effective; therefore,all T cells express only one T-cell receptor on the cell surface.

True

Immature T cells failing to successfully recombine a β-chain locus die by apoptosis.

Apoptotic T cells are ingested by medullary epithelial cells.

T-cell receptor rearrangements have many features in common with immunoglobulin rearrangement,including the use of the RAG-1 and RAG-2 genes.

Premises:

The expression of the pre-T-cell receptor is required in order to halt β-,γ-,and δ-chain rearrangements.

Allelic exclusion of the T-cell receptor α and β chains is effective; therefore,all T cells express only one T-cell receptor on the cell surface.

Immature T cells failing to successfully recombine a β-chain locus die by apoptosis.

Apoptotic T cells are ingested by medullary epithelial cells.

T-cell receptor rearrangements have many features in common with immunoglobulin rearrangement,including the use of the RAG-1 and RAG-2 genes.

Responses:

False

True

Correct Answer:

Premises:

Responses:

The expression of the pre-T-cell receptor is required in order to halt β-,γ-,and δ-chain rearrangements.

Allelic exclusion of the T-cell receptor α and β chains is effective; therefore,all T cells express only one T-cell receptor on the cell surface.

Immature T cells failing to successfully recombine a β-chain locus die by apoptosis.

Apoptotic T cells are ingested by medullary epithelial cells.

T-cell receptor rearrangements have many features in common with immunoglobulin rearrangement,including the use of the RAG-1 and RAG-2 genes.

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