Which of the following statements are true of a T cell that expresses two α chains (and thus two different T-cell receptors) as a result of ineffective allelic exclusion of the α chain during rearrangement? (Select all that apply.)
A) Engaging either of the T-cell receptors on MHC molecules of the thymic epithelium will result in positive selection.
B) One of the T-cell receptors will be functional while the other will most probably be non-functional.
C) If either T-cell receptor binds strongly to self-peptides presented by self-MHC molecules,the thymocyte will be negatively selected.
D) One of the T-cell receptors may be autoreactive but escape negative selection because its peptide antigen is present in tissues other than the thymus.
E) Subsequent gene rearrangements may give rise to a γ:δ T-cell receptor.
Correct Answer:
Verified
Q3: Which of the following statements about Notch
Q4: Which of the following processes is not
Q5: If a double-negative thymocyte has just completed
Q6: Thymocytes that are not positively selected
A)undergo genetic
Q7: Which of the following is mismatched:
A)double-negative CD3-
Q9: Which of the following is the first
Q10: In which of the following ways does
Q11: _ of thymocytes is necessary to produce
Q12: Which of the following is the first
Q13: There are many parallels between the development
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