A.What are the two main checkpoints of B-cell development in the bone marrow?
B.What is the fate of developing B cells that produce (i)functional or (ii)nonfunctional heavy and light chains?
C.Explain how these two checkpoints correlate with the process of allelic exclusion that ensures that only one heavy-chain locus and one light-chain locus produce functional gene products.
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Q5: Large pre-B cells are characterized by which
Q6: When expression of _ is turned off
Q7: Which of the following statements is correct?
A)The
Q8: Which of the following would occur after
Q9: Immature B cells develop into B cells
Q11: You are going to use flow cytometry
Q12: Which of the following is not paired
Q13: All hematopoietic stem cells express
A)CD34
B)CD127
C)CD19
D)VpreBλ5
E)Pax-5
Q14: A defect in which of the following
Q15: Large pre-B cells undergo clonal expansion before
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