Negative Selection of Developing B Cells Ensures That

Negative selection of developing B cells ensures that

A) there is not an overabundance of circulating B cells that would compete with other important cell types in the circulation
B) only antigen-activated B cells leave the bone marrow
C) clonal expansion of B cells does not occur in the absence of infection
D) B-cell receptors that bind to normal constituents of the body do not emerge
E) B cells do not leave secondary lymphoid tissues.