Which of the following statements regarding T-cell receptor recognition of antigen is correct?

Question

Quizplus · Accepted Answer

T-cell receptors recognize antigen only as a peptide bound to an MHC molecule. This is because T-cell receptors recognize antigens through interactions with the combination of the antigenic peptide and the MHC molecule presenting it. This is a critical feature, as it ensures that T cells only respond to peptides presented by host cells and not to self-antigens that are not presented by MHC molecules. Option B is incorrect because T-cell receptors do not recognize antigen in their native form. Option C is incorrect because T-cell receptors do not recognize carbohydrates or lipids, as these molecules do not bind to MHC molecules. Option D is incorrect because antigen processing occurs primarily within cells, not extracellular spaces. Option E is incorrect because γ:δ T cells do not require MHC molecule presentation to recognize antigens.

Which of the Following Statements Regarding T-Cell Receptor Recognition of Antigen