What was likely the largest factor leading to the decline in Native American populations?

Name: What was likely the largest factor leading to the decline in Native American populations?
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Disease was the largest factor leading to the decline in Native American populations. Europeans brought with them diseases such as smallpox, measles, and influenza, for which Native Americans had no immunity. This led to devastating epidemics that wiped out large portions of Native American populations.

What Was Likely the Largest Factor Leading to the Decline