Explain how the use of sequencing technologies finally brought the search for the HD gene to a close as reported by the Huntington's Disease Collaborative Research Group.

Question

Quizplus · Accepted Answer

The Answer is Sequencing of the contigs that covered the end of Chromosome 4 that had been previously identified as the location of the HD locus revealed an "interesting contig" that contained a CAG repeat sequence.The population of individuals without HD had 17 alleles with CAG repeats varying from 11 to 34 copies.HD individuals had alleles with 42-66 repeats of the CAG trinucleotide.HD was known to be a trinucleotide repeat disease and the research group proposed HTT as the gene responsible for HD and named its gene product huntingtin.

Explain How the Use of Sequencing Technologies Finally Brought the Search